# The diffusion coefficient is the slope

So, we know that the equations describing Fick's First Law are analagous to the general equation for a straight line with a negative slope that intersects the origin (y = -mx), and so you should already have a pretty good idea of what the graph of this function will look like (the calculus version is below, but the discrete version would look exactly the same!).

In this case, the dependent variable is flux, and the independent variable is the gradient (dC/dx). Remember, dC/dx only looks scary. In reality it just means "the steepness of the gradient".

**But what is the biological meaning of the slope of the relationship?** Or, put
another way, how is the driving force (the gradient) translated into a response
(flux)? As we mentioned earlier, the constant in the equation gets its own name,
D (called the diffusion coefficient). **D is something that needs to be measured,
and it’s different for each unique situation (a particular molecule in
a particular medium at a particular temperature). **For example, the diffusion
coefficient of oxygen in water is a consistent value at room temperature, but
if you heat up the water, D goes up – the oxygen diffuses faster when
the temperature is higher or if you substitute molasses for water, D goes down
– oxygen has a hard time diffusing through molasses (and so would you!).
If a larger molecule (say, a protein) is diffusing through water, D will again
go down again, since big molecules move less and therefore diffuse more slowly
than small ones.

So what happens to flux if the diffusion coefficient changes? According to
Fick's first law, these quantities are directly proportional to each other (remember
the function is like y = mx) and -D is the slope. If you are interested in the
diffusion of glucose instead of oxygen, you get a different diffusion coefficient
D, and so the line has a different slope. In other words, **when
D is high, the same gradient causes more diffusion. **

So, we've spent a bit of time talking about this diffusion coefficient (D) - but what does that really represent biologically? One way to figure that out is just to look at the units of D to figure out what it is really describing.

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